Publications

Recent Publications 

CBTM supports multidisciplinary and collaborative research projects involving key institutions in Cambridge and beyond. Recent publications highlight how CBTM can facilitate both ongoing projects and new translational research proposals.

• Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN et al. (2020). SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. 181(5):1016-1035. 

• Sungnak W, Huang N, Bécavin C, Berg M, Queen R et al. (2020). SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nature Medicine. 26(5):681-687

• Moore L, Leongamornlert D, Coorens THH, Sanders MA, Ellis P et al. (2020) The mutational landscape of normal human endometrial epithelium. Nature. 580(7805) 640-646.

• Georgakopoulos N, Prior N, Angres B, Mastrogiovanni G, Cagan A et al. (2020) Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids. BMC Developmental Biology. Feb 26;20(1):4. 

• Park JE, Botting RA, Domínguez Conde C, Popescu DM, Lavaert M et al. (2020) A cell atlas of human thymic development defines T cell repertoire formation. Science. Feb 21;367(6480).

• James KR, Gomes T, Elmentaite R, Kumar N, Gulliver EL et al. (2020) Distinct microbial and immune niches of the human colon. Nature Immunology.  Mar;21(3):343-353.

• Martin JL, Costa ASH, Gruszczyk AV, Beach TE, Allen FM et al. (2019) Succinate accumulation drives ischaemia reperfusion injury during organ transplantation. Nature Metabolism 1;966-974.

• Madissoon E, Wilbrey-Clark A, Miragaia RJ, Saeb-Parsy K, Mahbubani KT et al. (2019) scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation. Genome Biology Dec 31;21(1):1.

• Lee-Six H, Olafsson S, Ellis P, Osborne RJ, Sanders MA et al. (2019) The landscape of somatic mutation in normal colorectal epithelial cells. Nature. 574(7779):532-537.

• Lok LSC, Dennison TW, Mahbubani KM, Saeb-Parsy K, Chilvers ER, Clatworthy MR (2019) Phenotypically distinct neutrophils patrol uninfected human and mouse lymph nodes. Proceeding of the National Academy of Sciences of USA. 16(38):19083-19089.

• Vieira Braga FA, Kar G, Berg M, Carpaij OA, Polanski K et al. (2019). A cellular census of human lungs identifies novel cell states in health and in asthma. Nature Medicine. Jul;25(7):1153-1163.

• Castro-Dopico T, Dennison TW, Ferdinand JR, Mathews RJ, Fleming A et al. (2019). Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis. Immunity 50(4):1099-1114.

• Martincorena I, Fowler JC, Wabik A, Lawson ARJ, Abascal F et al. (2018). Somatic mutant clones colonize the human esophagus with age. Science 362(6417):911-917. 

• Broutier L, Mastrogiovanni G, Verstegen M, Francies H, Gavarró L, Bradshaw C et al. (2017) Human primary liver cancer–derived organoid cultures for disease modeling and drug screening. Nature Medicine. 23(12):1424-1435.

• Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM et al. (2017). Reconstruction of the murine extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine 23(8):954-963.

• Tietjen GT, Hosgood SA, DiRito J, Cui J, Deep D et al. (2017) Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys. Science Translational Medicine 9(418).