The Cambridge Stem Cell Institute is dedicated to studying both normal and pathological stem cell behaviour with the aim of improving prevention, diagnosis and treatment of disease. The institute consists of 28 research groups looking at Stem Cell states, disease and therapeutics.
The Vallier Lab:
Professor Ludovic Vallier’s Lab focuses primarily on mechanisms controlling differentiation of pluripotent stem cells into definitive endoderm. Pluripotent stem cells are used to model embryonic development in vitro and to produce liver and pancreatic cells with the interest in cell therapy of liver failure and diabetes. The CBTM currently provides tissue used to development of cholangiocyte organoids for clinical applications and for the Study of liver cellular diversity for improved differentiation of hiPSC into mature hepatocytes.
The Laurenti Lab:
The Laurenti lab focuses on the study of haemapoietic stem cells (HSC) and progenitor cells with in vitro and in vivo single cell assays, transcriptomics and bioinformatics. The Laurenti Lab is currently receiving tissue from the CBTM for a multi-organ comparison of the human HSC and progenitor cell compartment.