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Cambridge Biorepository for Translational Medicine

Support for Multidisciplinary Translational Research

Studying at Cambridge

 

Research Themes

The CBTM serves to support multidisciplinary and collaborative research projects, covering a wide range of research themes, including:

 

Regenerative Medicine

The Huch Lab: Studies Primary Liver Cancer and Pancreatic cancer, stem cells and tissue regeneration, incorporating 'organoid' technology.

The Vallier Lab: Primarily studies embryonic development in vitro to produce liver and pancreatic cells with the interest in cellular therapies of liver failure and diabetes.

The Laurenti lab: focuses on the study of haemapoietic stem cells (HSC) and progenitor cells with in vitro and in vivo single cell assays, transcriptomics and bioinformatics.

Cancer Research

Jones Group: studies the alteration of normal cell behaviour through mutations in the early stages of cancer evolution

The fitzgerald lab: focuses on early detection and treatment of gastro-oesophageal cancers, aiming to understand the underlying mechanisms, improve upon diagnostic tools and molecular characterisation of oesophageal cancers. 

The Huch Lab: Primary Liver Cancer and Pancreatic cancer organoid technology.

Saeb-Parsy Lab: Safety and efficacy of cancer immunotherapies in humanised mouse models. 

Transplantation Research:

Saeb-Parsy Lab & Murphy Lab: Ischaemia-reperfusion injury in transplantation

Pettigrew Lab: Is primarily focused on research covering transplant rejection and immune homeostasis

The Bradley lab: is currently in the early stages of modelling human glomerulosclerosis in vitro.

Immunology:

Saeb-Parsy Lab: Currently has projects surrounding the function and immunogenicity of transplanted cellular therapies &  the safety and efficacy of cancer immunotherapies in humanised mouse models.

Kosmoliaptsis Lab: Primarily studies histocompatibility and Immunogenetics.

Pettigrew Lab: Transplant rejection and immune homeostasis

Clatworthy Lab:  Is focused on Immunoregulation, Immune cell metabolism in kidney/gut.

Jones Lab: Human autoimmunity in relation to recovery during T-cell Lymphopenia.

Genomics:

Human Cell Atlas: aims to create a comprehensive reference maps of all human cells that can be used to define the cellular basis of health and disease

Teichman Group: research focuses on protein structure evolution, higher order protein structure and protein folding. Sarah Teichmen’s research uses genomic approaches to study global regulation of gene expression.

Martincorena Group: research focuses on the accumulation of somatic mutations throughout life.

Diabetes and Obesity:

The Gribble Lab & The Reimann Lab: are currently collaborating to research how gut hormones are released and their actions on target tissues.

Saeb-Parsy Lab: Cryopreservation of multi-cellular aggregates and bioengineered tissues.

Find out more about our Collaborators and their research themes here

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The CBTM serves to support multidisciplinary and collaborative research projects involving key institutions in Cambridge and beyond. Recent publications highlight how the CBTM can be utilised to support ongoing projects and facilitate new translational research.

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See the latest articles and reviews surrounding CBTM supported research

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