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Cambridge Biorepository for Translational Medicine

Support for Multidisciplinary Translational Research

Studying at Cambridge

 

Professor Sir Steven O' Rahilly

Professor Sir Steven O' Rahilly

Co-Director, IMS

Director, University of Cambridge Metabolic Research Laboratories

Director, MRC Metabolic Diseases Unit

Professor of Clinical Biochemistry and Medicine


Research Theme

Prof O' Rahilly has a long-standing interest in the aetiology and pathophysiology of human metabolic and endocrine disease and how such information might be used to improve diagnosis, prognostication, therapy and prevention. He has a long-standing, close, collaboration with Sadaf FarooqiTony Colland Giles Yeo, which focuses onMechanisms in disorders of energy balance.

In these studies, they use human genetic and physiological approaches, accompanied by studies in cellular and animal disease models to better understand the biological causes of highly penetrant forms of human obesity and also the mechanisms whereby more common genetic variants predispose to common forms of obesity. This work has been incorporated into a research programme at the MRC Metabolic Diseases Unit (MDU) which formed in 2013.

 

Prof O'Rahilly holds a Wellcome Trust Senior Investigator Award focused on Mechanisms of Human Insulin Resistance. In this work he collaborates closely with David Savage and Robert Semple. They use human genetic and physiological approaches, accompanied by studies in cellular and animal disease models to better understand the biological causes of extreme forms of human insulin resistance and also the mechanisms whereby more common genetic variants predispose to common forms of the metabolic syndrome.

 

Both of these programmes benefit greatly from extensive interactions with Ines Barroso and with Nick Wareham and colleagues in the MRC Epidemiology Unit within the IMS.

 

More recently he has developed an interest in canine models of metabolic disease and in certain hormones of the gastro-intestinal tract (in collaboration with Fiona Gribble and Frank Reimann).